Last edited by Branris
Sunday, July 26, 2020 | History

5 edition of Enzyme induction and modulation found in the catalog.

Enzyme induction and modulation

  • 203 Want to read
  • 11 Currently reading

Published by M. Nijhoff, Distributors for the U.S. and Canada, Kluwer Boston in Boston, Hingham, MA .
Written in English

    Subjects:
  • Enzyme induction.,
  • Liver cells.,
  • Cell culture.

  • Edition Notes

    Other titlesMolecular and cellular biochemistry.
    Statementedited by V.A. Najjar.
    SeriesDevelopments in molecular and cellular biochemistry
    ContributionsNajjar, V. A. 1914-
    Classifications
    LC ClassificationsQP601 .E517 1983
    The Physical Object
    Pagination325 p. :
    Number of Pages325
    ID Numbers
    Open LibraryOL3166355M
    ISBN 100898385830
    LC Control Number83008338
    OCLC/WorldCa9575135

    Purchase Quinones and Quinone Enzymes, Part B, Volume - 1st Edition. Print Book & E-Book. ISBN ,   Induction of the microsomal enzymes may also have other effects as well as the increased production of particular enzymes and isozymes. Here again the different types of inducer vary. Thus, the barbiturate type of inducer differs significantly from the polycyclic hydrocarbon type as can be seen from the list below.

    Sir, We have read the article, “Is cytochrome modulation the new frontier for decreasing the risk of cataract?” published in IJP, April [] with great study is based on the hypothesis excess glucose is converted to sorbitol (which can cause cataract) by enzyme aldose reductase using NADPH as a cofactor, and electron transfer from NADPH further depends on the cytochrome. Modulation of constitutive and inducible hepatic cytochrome(s) P by interferon beta in mice J Hepatol. Feb;24(2) doi: /s(96) Authors M Carelli 1 Enzyme Induction Interferon-beta / pharmacology* Isoenzymes / biosynthesis*.

    Enzyme-specific testing for drug interactions by in vitro techniques has become a routine practice in drug development. With many drugs, enzyme induction has similar importance for the prediction of drug−drug interactions. We developed a method for recognizing enzyme induction mediated via the aryl hydrocarbon receptor. This type of induction may be clinically important since experimental. coids at the level of both TAT enzyme and mRNA but not for two other glucocorticoid inducible genes in the same cells. These results, plus the fact that a similar difference in the concentration required for half-maximal TAT induction in FuS-5 cells was seen for both glucocorticoids and cyclic AMP, argue that the modulation occurs at some point.


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Enzyme induction and modulation Download PDF EPUB FB2

Nonsubstrate induction of a soluble bacterial cytochrome P monooxygenase by phenobarbital and its analogs Armand J. Fulco, Bok Hoi Kim, Robert S. Matson, Linda Owers Narhi, Richard T. Enzyme Induction and Modulation by V. Najjar,available at Book Depository with free delivery worldwide.

Enzyme Induction and Modulation. Editors: Najjar, V.A. (Ed.) Free Preview. Buy this book eBook ,39 *immediately available upon purchase as print book shipments may be delayed due to the COVID crisis. ebook access is temporary and does not include ownership of the ebook. Only valid for books with an ebook version.

Enzyme induction refers to an increase in the rate of hepatic metabolism, mediated by increased transcription of mRNA encoding the genes for drug-metabolizing enzymes. This leads to a decrease in the concentrations of drugs metabolized by the same enzyme.

Rifampicin is a potent inducer of CYP3A4 and can result in clinically significant decreases in plasma concentrations of many concomitant. Modulation of functional activities in cultured rat hepatocytes.- Regulation of expression of genes for enzymes of the mammalian urea cycle in permanent cell-culture lines of hepatic and non-hepatic origin.- The hormonal induction of gamma glutamyltransferase in rat liver and in a hepatoma cell line.- Plasma protein induction by isolated.

Enzyme Induction and Modulation | Thomas D. Gelehrter, Patricia A. Barouski-Miller, Patrick L. Coleman, Bernard J. Cwikel (auth.), V. Najjar (eds.) | download | B. Modulation of functional activities in cultured rat hepatocytes Regulation of expression of genes for enzymes of the mammalian urea cycle in permanent cell-culture lines of hepatic and non-hepatic origin The hormonal induction of gamma glutamyltransferase in rat liver and in a hepatoma cell line Plasma protein induction by isolated hepatocytes.

Csaba K. Zoltani, in Biomarkers in Toxicology (Second Edition), Cardiac Toxicity. Toxic compounds, including drugs, can directly affect the heart. Typical effects are the formation of lesions and biochemical changes, including enzyme induction or inhibition with changes in metabolic pathways.

One of the characteristics of our environment is the acceptance of the introduction and. (ebook) Enzyme Induction and Modulation () from Dymocks online store.

We are open, in-store and online. Some orders may experience a slight delay due to COVID restrictions. The induction of phase II detoxifying or antioxidant enzymes is one of the most important components of cellular defense mechanisms whereby a diverse array of electrophilic and prooxidative toxicants can be eliminated from the cell before they damage the target cell DNA (Kong et al., ).

ISBN: OCLC Number: Description: 1 online resource ( pages) Contents: I --Hormonal regulation of plasminogen activator in rat hepatoma cells --Cell types in rat liver cultures: their identification and isolation --Modulation of functional activities in cultured rat hepatocytes --Regulation of expression of genes for enzymes of the.

Chirality is a natural attribute nature of living matter and plays an important role in maintaining the metabolism, evolution and functional activities of living organisms. Asymmetric conformation represents the chiral structure of biomacromolecules in living organisms on earth, such as the L-amino acids of proteins and enzymes, and the D-sugars of DNA or RNA, which exist preferentially as one.

Enzyme induction and repression Microorganisms have many enzymes that function in the myriad of activities that produce a growing and dividing cell. From a health standpoint, some enzymes are vital for the establishment of an infection by the microbes.

Some enzymes are active all the time. These are known as constitutive enzymes. However, other enzymes are active only periodically, when their. Benzo[a]pyrene (BaP) is a well-studied pro-carcinogen that is metabolically activated by cytochrome P enzymes.

Cytochrome PA1 (CYP1A1) has been considered to play a central role in the activation step, which is essential for the formation of DNA adducts.

This enzyme is strongly induced by many different chemical agents, including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In this chapter, different mechanisms of metabolic regulation are discussed in terms of enzyme synthesis through transcription and translation and enzyme activity modulation.

Mechanisms regulating enzyme synthesis. The rate of biological reactions catalyzed by enzymes is determined by the concentration and activity of the enzymes. REVIEW Open Access Modulation of benzo[a]pyrene–DNA adduct formation by CYP1 inducer and inhibitor Kazuhiro Shiizaki1*, Masanobu Kawanishi2 and Takashi Yagi2 Abstract Benzo[a]pyrene (BaP) is a well-studied pro-carcinogen that is metabolically activated by cytochrome P enzymes.

Modulation of enzyme activity was achieved through both downregulation [(small interfering RNA (siRNA)] and induction (pregnane X receptor agonist rifampicin) of CYP3A4. Taking advantage of the long-term cell survival of the HepatoPac model, it was also possible to permit enzyme recovery after removal of the modulators (siRNA and rifampicin).

The induction of CYP1A2 is mediated by binding of polycyclic aromatic hydrocarbons of the tobacco smoke to the aryl hydrocarbon receptor (AHR) with consequent transcriptional activation of the CYP1A2 gene.

Furthermore, CYP1A1 and CYP1B1 enzymes are induced by tobacco smoking via AHR in various human tissues such as lung and placenta. As CYP1A1. In this paper, the term induction refers only to the commonly-known biological process involving chemical-stimulated transcription of a CYP gene followed by translation of its mRNA, which results in increased de novo biosynthesis and elevated intracellular levels of the CYP protein.

Although a chemical may also increase the steady-state concentrations of a CYP isoform in a cell by affecting. Book Descriptions: In addition to performing its prime function as a vehicle for scientific communications of varied colora tions, Molecular and Cellular Biochemistry is again focusing on two subjects which it treats in depth.

One of these is a book issue dealing with the transglutaminase reaction. The other is this issue that deals with induction and modulation of enzymes.

The inhibition of P-gp activity was determined as a reflection of increase in calcein-AM uptake. Additionally, the enzyme induction potential of the extracts was assessed through the modulation of PXR activity in HepG2 cells transiently transfected with pSG5-PXR and PCR5 plasmid DNA.CYP1A1 and CYP3A4 modulation by dietary flavonoids in human intestinal Caco-2 cells at least partly, direct interactions at the enzyme level.

Quercetin was also shown to significantly inhibit the constitutive CYP3A4 activity, measured by the 6beta-(OH)-testosterone assay, and to impair its induction by 1,vitamin D(3).

Chrysin, quercetin.The effect of a water extractable humic substances fraction (WEHS) on nitrate uptake and plasma membrane (pm) H+-ATPase activity of maize roots was investigated. Four days old maize root seedlings were exposed for 4 to 24 h to a nutrient solution containing μ M nitrate in the absence or presence of 5 mg org.

C { L -1 WEHS. Plants exposed to nitrate developed a higher capacity to absorb.